On October 14, Larry gave a keynote at the Atlanta Linux Showcase. The full text is available here. Below are the key points that are relevant to perl6. There are also links to mp3's and more.

These represent Larry's current thinking, not hard and fast design decisions

MP3 - (local copy).
Transcription (by Nathan Torkinton; extra proofreading thanks to Jan-Pieter Cornet)
Slides (mirrored) - (original)